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Symbol
Name
ID

Fgd4
FYVE, RhoGEF and PH domain containing 4
MGI:2183747

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased number of peripheral myelinated nerve fibers	Onion bulb formation	Peripheral hypomyelination	Decreased motor nerve conduction velocity	Areflexia	Hyporeflexia	Unsteady gait	Waddling gait	Motor delay	Hypoesthesia	Distal sensory impairment
Disease(s) Associated with FGD4
Charcot-Marie-Tooth disease type 4H

Mouse Phenotypes		nervous system phenotype	abnormal myelin sheath morphology	abnormal myelination	demyelination	abnormal nervous system electrophysiology	abnormal action potential	decreased nerve conduction velocity
Availability	Mouse Genotype	nervous system phenotype	abnormal myelin sheath morphology	abnormal myelination	demyelination	abnormal nervous system electrophysiology	abnormal action potential	decreased nerve conduction velocity
	Fgd4^tm1.1Ics/Fgd4^tm1.1Ics
	Fgd4^tm1Ics/Fgd4^tm1Ics Tg(Dhh-cre)1Mejr/0 (conditional)
	Fgd4^tm1Ics/Fgd4^tm1Ics Mnx1^tm4(cre)Tmj/Mnx1⁺ (conditional)	*
	Fgd4^tm1Ics/Fgd4^tm1Ics Tg(Plp1-cre/ERT2)1Ueli/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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